Jonathan N. Glickman, Inform Diagnostics Research Institute, Irving, TX
Collagenous colitis (CC) and lymphocytic colitis (LC) are chronic watery
diarrheal disorders that most commonly affect middle aged to elderly adults.
Since the colonic mucosa in each disorder appears endoscopically normal,
the diagnosis rests upon characteristic histologic findings in mucosal
biopsies. However, the histologic distinction between LC and CC, and between
CC/LC and other types of colitis, can be challenging. Typically, multiple
random colonic mucosal biopsies are taken for patients with suspected
CC and LC, and the diagnosis is based upon cumulative evaluation of multiple
fragments. However, the influence of biopsy sampling strategy on diagnostic
accuracy for CC and LC is poorly understood, and the utility of rectal
biopsies in evaluation of these disorders is not known.
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