Jonathan N. Glickman, Anuradha Singhal, Inform Diagnostics Research Institute,
Collagenous colitis (CC) and lymphocytic colitis (LC), collectively termed
microscopic colitis (MC), are chronic watery diarrheal disorders that
most commonly affect middle aged to elderly adults. The diagnosis rests
upon characteristic histologic findings in endoscopic mucosal biopsies,
which also distinguish MC from idiopathic inflammatory bowel disease (IBD)
[ulcerative colitis (UC) and Crohn’s disease (CD)]. MC and IBD have
different treatments, natural histories, and need for endoscopic surveillance.
However, the distinction between MC and IBD can be difficult at times
since they can share some histologic features. It has also been speculated
that these disorders may bear some relationship, at least in some individuals.
The objective of this study was to characterize patients in whom these
disorders present either synchronously or metachronously.
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