First described by Jules Haot in 1988, lymphocytic gastritis (LG) was initially
believed to correspond to an entity mentioned in 1945 by the Belgian gastroenterologist
François Moutier, who reported a nodular form of gastritis characterized
by centrally eroded or ulcerated depressions picturesquely compared to
gastric smallpox (“varioliform gastritis”) or to the tentacles
of an octopus (“octopus-sucker gastritis”). Amidst the flurry
of gastric pathology research that immediately followed the discovery of
H. pylori it soon became clear that increased lymphocytic infiltrates in the gastric
epithelium were also found in patients with celiac disease, Ménétrier’s disease,
H. pylori infection, lymphocytic and collagenous colitis, and users of NSAIDs. Histologic
evidence of gastric epithelial lymphocytosis has also been reported in
patients with an endoscopically normal gastric mucosa.
Thus, for years lymphocytic gastritis has remained relegated to a histopathologic
pattern without specificity for any particular disease entity.
One of the reasons for the failure to detect consistent clinicopathologic
correlations may have been the relatively small size of the series included
in most studies, in which less common associations might escape detection.
Also, the spectrum of gastric pathology in the industrialized world has
undergone a considerable shift over the past two decades, in part because
of the dramatic decline in the prevalence of
H. pylori infection and in part due to the widespread use of proton- pump inhibitors.
Thus, the 1990 paradigms may no longer be valid today.
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