Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel
Disease (IBD) is relatively uncommon. Compared to sporadic CRC, the molecular
pathogenesis of IBD-associated CRC has some distinctive features, particularly
the timing of acquisition of genetic changes during progression through
high-grade dysplasia. DNA mismatch repair (MMR) deficient sporadic CRC
is a well-defined entity comprised of Lynch syndrome-associated cancers
and cancers characterized by a CpG island methylator phenotype (CIMP).
The latter cancers characteristically arise in sessile serrated adenomas/polyps.
The role of MMR deficiency in IBD CRC is less well-established. We undertook
this study to determine the frequency and clinical pathologic associations
of MMR deficiency in IBD-associated neoplasia.
View the poster