The rates of primary and secondary syphilis have been increasing in the
United States since 2001, following a historic low in 2000.
The manifestations of syphilis as a genital disease are well described;
however, its presentation as primary anal canal disease remains relatively
Although the demonstration of serum antibodies has traditionally remained
the mainstay for diagnosis of syphilis in the past, pathologists occasionally
encounter an anal canal biopsy in which syphilis may be a consideration
in the histologic differential diagnosis.
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