Eosinophilic esophagitis (EoE) is a chronic, allergy-related disease in
which prolonged eosinophil-predominant inflammation can cause tissue remodeling.
The remodeling results in serious complications including esophageal rings,
strictures, and mucosal fragility, which can cause dysphagia, food impactions,
and painful mucosal tears. A feature of the remodeling is the pattern
of dense, subepithelial fibrosis in the lamina propria, and it is unclear
whether this subepithelial fibrosis is unique to EoE.
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