Published in May 2016 by
JAMA The Journal of the American Medical Association. Authors: Kerry B. Dunbar, MD, PhD; Agoston T. Agoston, MD, PhD; Robert
D. Odze, MD; Xiaofang Huo, MD, PhD; Thai H. Pham, MD; Daisha J. Cipher,
PhD; Donald O. Castell, MD; Robert M. Genta, MD; Rhonda F. Souza, MD;
Stuart J. Spechler, MD
Importance The histologic changes associated with acute gastroesophageal reflux disease
(GERD) have not been studied prospectively in humans. Recent studies in
animals have challenged the traditional notion that reflux esophagitis
develops when esophageal surface epithelial cells are exposed to lethal
chemical injury from refluxed acid.
Objective To evaluate histologic features of esophageal inflammation in acute GERD
to study its pathogenesis.
View the abstract