Urologic Oncology, 2015. Authors: Rajal B. Shah, M.D., Jianbo Li, Ph.D., Nadeem Dhanani,
M.D., Savvas Mendrinos, M.D.
The most important clinical significance of an isolated high-grade prostatic
intraepithelial neoplasia (HGPIN) diagnosis is the risk of missed prostate
cancer (PCa) in subsequent biopsies. Because most patients with HGPIN
do not harbor or develop PCa, clinical, pathological, or molecular markers
that predict PCa risk are of clinical significance.
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