E. Kroman, L. Scott, Q. Zhao, J. Zhang, T. Golding, M.L. Miller, W.L. Flejter
– Inform Diagnostics
Cytogenetic analysis of plasma cell disorders (PCD) is difficult owing
to their low proliferative rate in vitro. Although interphase fluorescence
in situ hybridization (FISH) has improved the detection of abnormalities,
cases with a low level of neoplastic cells often go undetected. Plasma
cell enrichment techniques increase the density of the overall population
of plasma cells, thereby increasing the detection and frequency of abnormalities.
In this preliminary study, bone marrow plasma cells from 21 patients with
a clinical suspicion of a PCD, and 20 normal control samples, were enriched
using the auto MACS Pro Separator.
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