Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.

Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” (IDC-P). IDC-P is almost always associated with clinically aggressive high-volume prostate carcinoma. However, cribriform HGPIN is a putative neoplastic precursor lesion and recent data have questioned whether HGPIN on needle biopsy is associated with a significantly increased cancer risk in subsequent biopsies, and therefore mandates rebiopsy within the first year after its diagnosis.