Scientific Publications
Recent publications in Gastroenterology
Inform Diagnostics fosters an academic environment where ongoing research and education are encouraged. Read the latest abstracts, articles, and publications from the GI pathologists at Inform Diagnostics.
Barrett’s Esophagus is Not Rare in Asian Patients Who Have Esophageal Biopsies Taken in the United States
National differences in the prevalence of Barrett’s esophagus (BE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
Influence of Patients’ Ethnicity on the Gastric Biopsy Sampling Patterns
Although the Sydney System protocol requires separate biopsy sampling from antrum, incisura, and corpus, less than 4% of U.S. endoscopists adhere to these recommendations. There are significant differences in the…
High Prevalence of Ulcerative Colitis in US Residents of Indian Origin
The prevalence of Inflammatory bowel disease (IBD), including both Crohn Disease (CD) and ulcerative colitis (UC) is reportedly high in Ashkenazi Jews, but it is believed to be very low…
The Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the United States Parallels the Incidence of Gastric Cancer in Their Corresponding Ancestral Countries
The epidemiology of H. pylori infection and the incidence of gastric cancer (GC) and its precursor lesions in different countries are well established. However, the consequences of such variability for…
Low Prevalence of Microscopic Colitis and Inflammatory Bowel Disease in Americans of East Asian Ancestry
East Asian countries have historically reported low incidences of microscopic colitis and inflammatory bowel disease (1); however, it is unclear whether these data reflect genetic or environmental factors or are…
Ethnic Distribution of Atrophic Autoimmune Gastritis in the United States
Autoimmune Atrophic Gastritis (AIG) has classically been associated with “elderly women of Northern European ancestry.” (Friedlander, Am. J. Med. Sci,1934) Several epidemiologic studies have shown equal prevalence in various ethnic…
Gastric Antral Vascular Ectasia: The Invaluable Role of the Gastric Biopsy in its Detection and Confirmation
Gastric vasculopathies consist predominantly of two entities: Gastric antral vascular ectasia (GAVE)Portal hypertensive gastropathy (PHG) The classically described GAVE patient is an elderly woman with iron-deficiency anemia and a “watermelon”…
Gastric Polyps: Shifting Paradigms in the Twilight of Helicobacter
H. pylori infection is declining in the industrialized world and emerging economies. Simultaneously, as the world population moves to a “Western” diet, obesity and gastroesophageal reflux disease are on the…
Correlation of P16 Expression and Clinicopathologic Outcome of Anal Squamous Cell Carcinoma
Anal squamous cell carcinoma (ASCC) is uncommon, and accounts for 4% of carcinomas involving the gastrointestinal tract. The pathogenesis of ASCC is still unknown. Many studies have shown a strong…
Submucosal Lipoma and Sessile Serrated Adenoma/Polyp, More Than Just a Coincidence?
In our practice we noticed that sessile serrated adenomas/polyps (SSA/P) were frequently associated with submucosal lipomas (SL). While this finding has been reported by other experts, it is unclear if…
Isolated Eosinophilic Colitis: A Challenging Diagnosis in Search of Criteria
Eosinophils infiltrate the colonic mucosa in response to tissue-invading parasites, as part of eosinophilic gastroenteritis (EoG), or as an isolated presumably allergic phenomenon. Focal infiltrates around parasite fragments are easily…
Gastric Antral Vascular Ectasia: Relevance of the Histopathologic Diagnosis
Gastric Antral Vascular Ectasia (GAVE) is traditionally considered an endoscopic diagnosis. Because the role of the gastric biopsy is uncertain, and the relatively obscure criteria proposed by Gilliam (Dig Dis…
Duodenal Adenomas Coincide with Colorectal Neoplasia
Published by Digestive Diseases and Sciences, April 6, 2014 Robert M. Genta, MD, Jennifer M. Hurrell, DO, Amnon Sonnenberg, MD, MSc Small case series have alluded to an association between…
Help us help you! A Practical Approach to Biopsying the GI Tract (Part 2)
Part 2 — Lower GI tract See Part 1 — Upper GI tract Optimal biopsy sampling will help your expert Inform Diagnostics GI pathologist to render a specific and accurate…
Help us help you! A Practical Approach to Biopsying the GI Tract (Part 1)
Part 1—Upper GI tract Optimal biopsy sampling will help your expert Inform Diagnostics GI Pathologist to render a specific and accurate diagnosis. In the gastrointestinal tract, it is often important…
The Intradepartmental Consultation: Collaborative Teamwork at its Best
There are many quality-control measures and programs in place at Inform Diagnostics Life Sciences that complement our expertise, ensure the highest quality, and promote the most accurate diagnoses. Among them…
Helicobacter-negative Chronic Active Gastritis is an Independent Nosologic Entity, Not Merely Missed Helicobacter Infection: A Nationwide Study of 600,000 Patients
Helicobacter-negative chronic active gastritis is a histopathologic entity characterized by diffuse chronic active inflammation in a pattern typically encountered in H. pylori gastritis, but with no organisms detectable by conventional…
HER2 Testing: A New Hope for Patients with Gastric and Gastro-Esophageal Adenocarcinoma
Gastric cancer is associated with substantial morbidity and mortality worldwide. It is the second most common cause of cancer-related deaths globally.1 In the United States, the majority of patients with…
Esophageal Eosinophilia and Gastric Mucosal Pathology: Is There a Link?
We have previously reported, and others have confirmed, an inverse relationship between eosinophilic esophagitis and Helicobacter pylori gastritis. Other conditions affecting the stomach can include reactive gastropathy, autoimmune atrophic gastritis,…
Understanding the behavior and progression of sessile serrated adenomas
As pathologists, diagnostic excellence is always our goal. Even so, we are often stymied by differences in terminology, inconsistent application of microscopic criteria and insufficient large-scale studies. These differences make…