Scientific Publications
Recent publications in Gastroenterology
Inform Diagnostics fosters an academic environment where ongoing research and education are encouraged. Read the latest abstracts, articles, and publications from the GI pathologists at Inform Diagnostics.
Atrophic Autoimmune Gastritis: Manifestations and Clinicopathologic Associations in a Large United States Cohort
Atrophic autoimmune gastritis (AIG) is uncommon and most series include few patients. An accurate diagnosis rests on adequate gastric biopsy sampling (rarely done); thus, controls have often been subjects in…
Higher Prevalence of Celiac Disease in the Microscopic Colitis Population: Results From a Large Pathology Database
Microscopic colitis (MC) refers to two medical conditions which cause chronic diarrhea: collagenous colitis (CC) and lymphocytic colitis (LC). Previous studies have reported an increased prevalence of microscopic colitis in…
Epithelial Dysplasia and Cancer in IBD Strictures
The presence of colonic strictures and epithelial dysplasia are both known risk factors for the occurrence of colorectal cancer (CRC) in IBD patients. The aim of the present case-control study…
Same-day Bidirectional Endoscopy: Patients or Practice?
A subset of patients undergo both EGD and colonoscopy on the same day (bidirectional endoscopy or BDE). Although no clear guidelines exist, same-day bidirectional endoscopy has been recommended for patients…
The Aging of the American Stomach: Entering the Post-Helicobacter Era?
Physiologic decline occurs in the stomach of every aging human, but pathologic conditions are affected by genetic and environmental factors. Worldwide, the most important of these is believed to be…
The Cecal Patch is Associated with a Greater Prevalence of Symptoms in Patients with Ulcerative Colitis
The cecal patch is defined as the discontinuous involvement of the cecum in patients with otherwise left-sided ulcerative colitis (UC); see Figures 1 and 2. Several studies have failed to…
Lymphocytic Gastritis: An Expression of Different Diseases
First described by Jules Haot in 1988, lymphocytic gastritis (LG) was initially believed to correspond to an entity mentioned in 1945 by the Belgian gastroenterologist François Moutier, who reported a…
Hepatopathology Services from Inform Diagnostics
While Inform Diagnostics is recognized as a leading provider of academic-caliber GI pathology diagnostic services, did you know about our expertise in hepatopathology? Several pathologists at Inform Diagnostics have extensive…
Recognition of the p53 Null Staining Pattern Increases the Detection of p53 Alterations in Inflammatory Bowel Disease-Associated Carcinomas
Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Mutations in p53 have been found in these cancers, and have been proposed as a…
Clinical and Histologic Spectrum of NSAIDs-Induced Injury in the Right Colon
Non-steroidal anti-inflammatory drugs (NSAIDs) are a significant cause of morbidity and mortality. In the upper gastrointestinal (GI) tract, NSAIDs are known to cause ulcers/erosions and even perforation. Lower GI tract…
Reactive Gastropathy is Associated with Inflammatory Conditions Throughout the Gastrointestinal Tract
Reactive gastropathy is a histopathologic term widely understood by gastroenterologists as an indication of gastric damage associated with either bile reflux or chronic NSAID use. The epidemiology of reactive gastropathy…
Immunohistochemical Staining for p53 Protein in Barrett’s Esophagus
An Emerging Ancillary Technique in Risk Stratification The diagnosis of dysplasia in the setting of Barrett’s esophagus is one of the most challenging areas of GI pathology and is associated…
American College of Gastroenterology: 2011 Annual Scientific Meeting
Another Major Presence for Inform Diagnostics Washington, D.C. – For the past four years, the conspicuous presence of researchers from Inform Diagnostics has become a tradition at the annual meeting…
Barrett’s Metaplasia and Colonic Neoplasms Coincide in Identical Patients
More than 25 years ago, Sontag et al first reported an increased prevalence of colonic neoplasms in patients with Barrett’s esophagus. Many subsequent articles have been published, trying to confirm…
Lymphocytic Esophagitis: Shedding Fresh Light on a Mysterious Histopathologic Pattern
You may have received pathology reports with a diagnosis of “lymphocytic esophagitis pattern of injury” and asked youself two perfectly reasonable questions: 1. “Well, what does that mean?” 2. “Is…
CMV Colitis in Patients Undergoing Colonoscopy in Community-Based Endoscopy Centers
Reenu K. Malhotra, Anuradha Singhal, Robert M. Genta, Inform Diagnostics Research Institute, Irving, TX Clinically apparent cytomegalovirus (CMV) colitis in adults is most frequently found in immunosuppressed patients, although sporadic…
Collagenous Colitis: A Clinical and Demographic Review of 2,368 Cases
Jeremy S. Ditelberg MD, Inform Diagnostics Research Institute, Newton, MA High-grade dysplasia (HGD) in colorectal adenomas is relevant for follow-up and management of patients with polyps. While some authors advocate…
Miraca Life Sciences Highlights at DDW 2011
At DDW this past May, Inform Diagnostics pathologists once again had a significant presence with two abstracts presented as oral platform presentations and six posters. Below are the two platform…
High-Grade Dysplasia in Colonic Adenomas Among 600,000 Colonoscopy Patients
M.H. Saboorian, R.H. Lash, Inform Diagnostics Research Institute, Irving, TX High-grade dysplasia (HGD) in colorectal adenomas is relevant for follow-up and management of patients with polyps. While some authors advocate…
Hyperplastic Polyp of the Colon: Age and Gender Distribution of 65,453 Cases
Jeremy S. Ditelberg MD, Inform Diagnostics Research Institute, Newton, MA The hyperplastic polyp (HP) is the most common polyp of the colon. This study examined 65,453 cases of HP in…
