Mei-Yu Hsu, MD, PhD
Academic Appointments
2010–2016 Associate Professor of Dermatology, Boston University
2006–2010 Assistant Professor of Pathology, Harvard Medical School
2005–2006 Assistant Professor, Molecular Biology Graduate Program, University of Iowa
2003–2006 Assistant Professor, Pathology and Dermatology, University of Iowa
Postdoctoral Training
2002-2003 Fellow, Dermatopathology, UT Southwestern Medical Center
1998-2003 Visiting Scientist, Tumor Biology, Wistar Institute
1998-2002 Resident, Pathology, Thomas Jefferson University Hospital
1997-1998 Fellow, Tumor Biology, Wistar Institute
Education
1997 PhD, University of Pennsylvania
1992 MD, Kaohsiung Medical University
Certifications
Dermatopathology
Anatomic and Clinical Pathology
Standard ECFMG
Select Publications
Hsu MY, Yang MH, Schnegg CI, Hwang S, Ryu B, Alani RM. Notch3 signaling-mediated melanoma endothelial crosstalk regulates melanoma stem-like cell homeostasis and niche morphogenesis. Lab Invest. 2017 Jun; 97(6):725–736.
Schnegg CI, Yang MH, Ghosh SK, Hsu MY. Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma. Cancer Res. 2015 Apr 15; 75(8):1682–90.
Mak AB, Schnegg C, Lai C-Y, Yang MH, Ghosh S, Moffat J, Hsu M-Y. CD133-targeted niche-dependent therapy in cancer: A multi-pronged approach. Am J Pathol. 2014; 184(5):1256–62.
Pinc A, Somasundaram R, Wagner C, Hormann M, Karanikas G, Jalili A, Bauer W, Brunner P, Grabmeier- Pfistershammer K, Gschaider M, Lai, C, Hsu M-Y, Herlyn M, Sting G, Wagner S. Targeting CD20 in melanoma patients at high risk of disease recurrence. Mol Ther. 2012; 20:1056–1062.
Lai C-Y, Schwartz BE, Hsu M-Y. CD133+ melanoma subpopulations contribute to perivascular niche morphogenesis and tumorigenicity through vasculogenic mimicry. Cancer Res. 2012; 72(19):5111–5118.
De Luca A, Laumura L, Strizzi L, Roma C, Antonio AD, Margaryan N, Pirozzi G, Hsu M-Y, Botti G, Mari E, Hendrix MJC, Salomon DS, Normanno N. Expression and functional role of CRIPTO-1 in cutaneous melanoma. Br J Cancer. 2011; 105:1030–1038.
Van Otterloo E, Li W, Bonde G, Day KM, Hsu MY, Cornell RA. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet. 2010 Sep 16; 6(9):e1001122.
McAllister JC, Zhan Q, Weishaupt C, Hsu MY, Murphy GF. The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts. J Cutan Pathol. 2010 Apr; 37 Suppl 1:19–25.
Laga AC, Lai C-Y, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu M-Y, Murphy GF. Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and Merkel cell biology. Am J Pathol. 2010; 176:903–913.
Martin, JE, Hsu M-Y, Wang LC. A unique clinical presentation of multiple tumors of the follicular infundibulum. J Am Acad Dermatol. 2009; 60:885–886.
Menke J, Hsu M-Y, Byrne KT, Lucas JA, Rabacal WA, Croker BP, Zong X-H, Stanley ER, Kelley VR. Sunlight triggers cutaneous lupus through a colony stimulating factor-1 (CSF-1) dependent mechanism in MRL-Faslpr mice. J Immunol. 2008; 181:7367–7379.
Hsu M-Y, Rovinsky S, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF. Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest. 2008; 88:842–855. (Editorial highlight in: Lab Invest. 2008; 88:795).
McNeill MS, Paulsen J, Bonde G, Burnight E, Hsu M-Y, Cornell RA. Cell death of melanophores in zebrafish trmp7 mutant embryos depends on melanin synthesis. J Invest Dermatol. 2007; 127:2020–2030.
