High-grade, poorly differentiated, infiltrative carcinomas involving the renal sinus region often pose challenging differential diagnostic considerations, specifically differentiation of urothelial […]
Abstract Category: Urology
Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.
Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” […]
ERG overexpression and multifocality predict prostate cancer in subsequent biopsy for patients with high-grade prostatic intraepithelial neoplasia
Accepted to Urologic Oncology, 2015. Authors: Rajal B. Shah, M.D., Jianbo Li, Ph.D., Nadeem Dhanani, M.D., Savvas Mendrinos, M.D. The […]
Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and Management
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen […]
Carcinoma of the Collecting Ducts of Bellini and Renal Medullary Carcinoma: Clinicopathologic Analysis of 52 Cases of Rare Aggressive Subtypes of Renal Cell Carcinoma With a Focus on Their Interrelationship
Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma are rare aggressive renal tumors. First described in 1949, […]
Predictive Value of ERG Oncoprotein Expression and Pathologic Parameters In the Stratification of Prostate Cancer Risk Associated With High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Diagnosis In Prostate Needle Biopsy
This research was presented at the AUA annual conference in May 2015, in New Orleans. High-grade prostatic intraepithelial neoplasia (HGPIN) […]
PTEN Protein Loss and Genomic Deletions in Prostate Cancer: A Comparative Study of Immunohistochemistry and Four-Color FISH Assay
PTEN (phosphatase and tensing homolog) on chromosome 10q23 is a key tumor suppressor gene that is deleted or inactivated in […]
Incidence and Clinicopathological Characteristics of Gleason Pattern 5 Prostate Cancer in Contemporary Needle Biopsies Series: A Prospective Study
Management of patients with prostate adenocarcinoma (PCa) heavily depends on the Gleason score assigned on prostate needle biopsy (NBX). The […]
Heterogeneity of PTEN and ERG Biomarkers Expression in Prostate Cancer Needle Biopsies with More Than One Core Positive: Implications for Biomarkers Sampling Strategy
Both PTEN and ERG biomarkers demonstrate significant inter- and intra-tumor core staining heterogeneity, suggesting that sampling may affect biomarkers interpretation. […]
Anal Canal Syphilis: A Challenging Diagnosis for the Gastrointestinal Pathologist
The rates of primary and secondary syphilis have been increasing in the United States since 2001, following a historic low […]
