Categorized: Abstracts & Presentations, Urology
Incidence and Clinicopathological Characteristics of Gleason Pattern 5 Prostate Cancer in Contemporary Needle Biopsies Series: A Prospective Study
Management of patients with prostate adenocarcinoma (PCa) heavily depends on the Gleason score assigned on prostate needle biopsy (NBX).
The presence of a Gleason pattern 5 (GP5) PCa is associated with disease progression and the worst clinical outcome. Patients with GP5 are often not amenable to surgical intervention, instead receiving hormonal and radiation therapy.
Previous studies have demonstrated that GP5 is underdiagnosed by pathologists.
Due to its poor clinical significance, the 2005 International Society of Urologic Pathologist (ISUP) modification of Gleason grading system recommends upgrading of tertiary GP5 in prostate NBX to a secondary Gleason pattern regardless of how small the amount of GP5 might be.