Categorized: Urology
PTEN Protein Loss and Genomic Deletions in Prostate Cancer: A Comparative Study of Immunohistochemistry and Four-Color FISH Assay
PTEN (phosphatase and tensing homolog) on chromosome 10q23 is a key tumor suppressor gene that is deleted or inactivated in 30-40% of clinically localized prostate cancers (PCa) and is frequently associated with high risk PCa.
Loss of PTEN tumor suppressor gene is increasingly being analyzed on prostate core biopsies (NBXs) due to its prognostic relevance in cancer (PCa) risk stratification.
