Scientific Publications
Recent peer-reviewed publications
At Inform Diagnostics, we are proud of the peer-reviewed research our pathologists have published, including pioneering work in their areas of subspecialty expertise.
Assessment of prospectively assigned Likert scores for targeted MR imaging-transrectal US fusion biopsies in patients with suspected prostate cancer
Published in Journal of Urology, 2016. Authors: Costa D, Lotan Y, Rofsky NM, Roehrborn C, Liu A, Hornberger B, Xi Y, Francis F, and Pedrosa I. For a copy, please contact Inform…
An initial negative round of targeted biopsies in men with highly suspicious multiparametric magnetic resonance findings does not exclude clinically significant prostate cancer-preliminary experience
Published in Urologic Oncology, April 2017. Authors: Costa DN, Kay FU, Pedrosa I, Kolski L, Lotan Y, Roehrborn CG, Hornberger B, Xi Y, Francis F, and Rofsky NM. For a copy,…
Optimal sampling scheme in men with abnormal multiparametric MRI undergoing MRI-TRUS fusion prostate biopsy
Published in Urologic Oncology, January 2019. Authors: Freifeld Y, Xi Y, Passoni N, Woldu S, Hornberger B, Goldberg K, Bagrodia A, Raj G, Margulis V, Cadeddu JA, Lotan Y, Francis F,…
Molecular Subtyping of Clinically Localized Urothelial Carcinoma Reveals Lower Rates of Pathological Upstaging at Radical Cystectomy Among Luminal Tumors
Published in European Urology, August 2019. Authors: Lotan Y, Boorjian SA, Zhang J, Bivalacqua TJ, Porten SP, Wheeler T, Lerner SP, Hutchinson R, Francis F, Davicioni E, Svatek RS, Chen CL,…
Utility of PTEN and ERG Immunostaining for Distinguishing High-grade PIN from Intraductal Carcinoma of the Prostate on Needle Biopsy
Published in The American Journal of Surgical Pathology, 2015. Authors: Morais CL, Han JS, Gordetsky J, Nagar MS, Anderson AE, Lee S, Hicks JL, Zhou M, Magi-Galluzzi C, Shah RB, Epstein…
Heterogeneity of PTEN and ERG Expression in Prostate Cancer on Core Needle Biopsies: Implications for Cancer Risk Stratification and Biomarker Sampling
Published in Human Pathology, 2015. Authors: Shah RB, Bentley J, Jeffery Z and DeMarzo AM. For a copy, please contact Inform Diagnostics.
Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent
Published in The American Journal of Clinical and Experimental Urology, 2015. Authors: Begley LA, Kasina S, Shah RB, and Macoska JA. For a copy, please contact Inform Diagnostics.
ERG overexpression and multifocality predict prostate cancer in subsequent biopsy for patients with high-grade prostatic intraepithelial neoplasia
Published in Urologic Oncology, 2015. Authors: Shah RB, Li J, Dhanani N, and Mendrinos S. For a copy, please contact Inform Diagnostics.
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists
Published in The American Journal of Surgical Pathology, September 2015. Authors: Shah RB, Li J, Cheng L, Egevad L, Deng FM, Fine SW, Kunju LP, Melamed J, Mehra R, Osunkoya AO, Paner…
Diagnosis of “poorly formed glands” Gleason pattern 4 prostatic adenocarcinoma on needle biopsy: an interobserver reproducibility study among urologic pathologists with recommendations
Published in The American Journal of Surgical Pathology, October 2015. Authors: Zhou M, Li J, Cheng L, Egevad L, Deng FM, Kunju LP, Magi-Galluzzi C, Melamed J, Mehra R, Mendrinos S, Osunkoya…
Improvement in inter-observer reproducibility in resolving an “Atypical glands suspicious for prostate cancer” diagnosis in prostate biopsies using a novel “Diseased focused diagnostic review” quality process
Published in Human Pathology, 2016. Authors: Shah RB, Leandro G, Romerocases G, Bentley J, Yoon J, Mendrinos S, Tadros Y, Tian W, and Lash R. For a copy, please contact Inform Diagnostics.
Atypical intraductal proliferation and intraductal carcinoma of the prostate on core needle biopsy: a comparative clinicopathological and molecular study with a proposal to expand morphological spectrum of intraductal carcinoma
Published in Histopathology, November 2017. Authors: Shah RB, Yoon J, Liu G, and Tian W. For a copy, please contact Inform Diagnostics.
GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall
Published in Histopathology, July 2017. Authors: Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, and Gordetsky J. For a copy, please contact Inform Diagnostics.
PTEN loss in prostatic adenocarcinoma correlates with specific adverse histologic features (intraductal carcinoma, cribriform Gleason pattern 4 and stromogenic carcinoma
Published in Prostate, August 2019. Authors: Shah RB, Shore KT, and Tian W. For a copy, please contact Inform Diagnostics.
Urine cytology diagnostic patterns before and after implementing the paris system for reporting urine cytology: a large single institutional study of over 27,000 cases
In prep. Authors: Tian W, Shore KT, and Shah RB. For a copy, please contact Inform Diagnostics.
Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants
Motaparthi K, Kapil JP and Velazquez EF. Adv Anat Pathol. 2017; 24(4):171–194.
The diagnostic use of ERG in resolving an “atypical glands suspicious for cancer” diagnosis in prostate biopsies beyond that provided by basal cell and α-methylacyl-CoA-racemase markers.
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen in ~50% of prostate carcinomas (PCas) and ~20% of high-grade…
Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: Impact of mandatory central pathology review at a large referral hospital
Urothelial carcinoma (UC) has peculiar capacity to undergo variant or divergent histological differentiation into a gamut of different histology types. UC demonstrating variant histological differentiation is associated with poor outcomes,…
p63, CK7, PAX8, and INI-1: An optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
High-grade, poorly differentiated, infiltrative carcinomas involving the renal sinus region often pose challenging differential diagnostic considerations, specifically differentiation of urothelial carcinoma (UC) from renal cell carcinoma (RCC) subtypes. Accurate diagnosis…
Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.
Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” (IDC-P). IDC-P is almost always associated with clinically aggressive high-volume…
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