Scientific Publications
Recent publications in Gastroenterology
Inform Diagnostics fosters an academic environment where ongoing research and education are encouraged. Read the latest abstracts, articles, and publications from the GI pathologists at Inform Diagnostics.
Therapeutic Drug Monitoring of Monoclonal Antibody in Inflammatory Bowel Diseases: Laboratory Evidence to Predict Patient Responses
Authors are Yun Wang, PhD, Kevin Turner, DO, Ahmed Bedeir, MD, Parag Patel, DO, and James Gulizia, MD, PhD. This abstract was awarded “Outstanding Abstract” in the 2018 Therapeutic Drug…
Quantification of the duodenal eosinophil content in adults: anecessary step for an evidence-based diagnosis of duodenaleosinophilia
Genta RM, Sonnenberg A, Turner K. Aliment Pharmacol Ther. 2018;00:1–8. The normal content of eosinophils in the adult duodenum remains undefined. Therefore, there is no foundation for evidence-based criteria to…
Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes
Published in May 2016 by JAMA The Journal of the American Medical Association. Authors: Kerry B. Dunbar, MD, PhD; Agoston T. Agoston, MD, PhD; Robert D. Odze, MD; Xiaofang Huo,…
Healthcare Cost of Over-Diagnosis of Low-Grade Dysplasia in Barrett’s Esophagus
Published online by Advances in Therapy, 2016. Authors: Richard H. Lash, Thomas M. Deas, Jr., Frank H. Wians, Jr. Published reports have demonstrated that many Barrett’s esophagus patients are over-diagnosed…
Geographic Distributions of Microscopic Colitis and Inflammatory Bowel Disease in the United States
Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by similar geographic distributions. We used a large database of pathology reports to analyze the geographic distribution of microscopic colitis (MC)…
Inverse Association of Esophageal Eosinophilia With Helicobacter pylori Based on Analysis of a US Pathology Database
Evan S. Dellon, Anne F. Peery, Nicholas J. Shaheen, Douglas R. Morgan, Jennifer M. Hurrell, Richard H. Lash, Robert M. Genta Published in Gastroenterology, 2011. Eosinophilic esophagitis (EoE) is of…
Lymphocytic oesophagitis: clinicopathological aspects of an emerging condition
Salima Haque, Robert M. Genta Published in Gut, 2012 Lymphocytic oesophagitis (LyE) has been reported in small series, but no consistent clinical correlations have emerged. The authors sought to determine…
Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups
Robert C. Kapel, Jocelyne K. Miller, Carlos Torres, Saime Aksoy, Richard Lash, And David A. Katzka Published in Gastroenterology, 2008 Most reports on eosinophilic esophagitis (EE) are limited to small…
Signet Ring Cell Carcinoma of the Esophagus
Signet ring cell carcinoma is a histologic variant of adenocarcinoma characterized by a population of loose tumor cells whose cytoplasm appears almost entirely occupied by mucin. In rare instances, signet…
Demographic and Socio-economic Influences on H. pylori-induced Changes to the Gastric Mucosa
Over a lifetime, gastric infection with Helicobacter pylori (Hp) can lead to chronic active gastritis (CAG), chronic inactive gastritis (CIG), intestinal metaplasia (IM) and atrophy (ATR). Little is known whether…
The Endoscopically Normal Stomach: Is It Worth a Biopsy?
In the absence of endoscopically visible lesions (such as tumors or ulcers), the gross appearance of the gastric mucosa is not believed by some gastroenterologists to be a reliable predictor…
Helicobacter pylori Gastritis: Atypical Infections May Be Missed Without the Regular Use of Special Stains
In most patients, Helicobacter pylori infection causes chronic active gastritis, a pattern that prompts pathologists to search for organisms, including the use of special or immunohistochemical stains. As a consequence…
Low Prevalence of Villous Atrophy (Marsh 3) in Duodenal Biopsies from Americans of East Asian and Hispanic Ancestry and High Prevalence in Northern Indians
East Asian countries have historically reported low prevalences of celiac disease (CD). Data from Latin America are more varied, but rates similar to those found in Europe and the United…
Pathogenetic Differences in the Progression of MLH1 Intact and Deficient Sessile Serrated Adenomas
Sessile serrated adenomas/polyps (SSA) are members of the serrated polyp family, often right sided, and are characterized by wide-bottomed crypts, disordered maturation, and dystrophic goblet cells histologically (Figure 1). SSAs…
Subepithelial Fibrosis is a Distinctive Characteristic of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic, allergy-related disease in which prolonged eosinophil-predominant inflammation can cause tissue remodeling. The remodeling results in serious complications including esophageal rings, strictures, and mucosal fragility,…
Intestinal Metaplasia of the Inlet Patch: Clinical and Pathological Associations
Heterotopic gastric mucosa (HGM) located in the proximal esophagus is referred to as “inlet patch.” Although its prevalence is reported to be around 4%, the inlet patch is infrequently biopsied.…
Granulomas in Crohn’s Disease are Associated With More Severe Disease Expression
The relevance of granulomas in the histopathology of patients with Crohn’s disease is largely unknown. Most previous studies have relied on small case series. The aim of our study was…
Ethnic Distribution of Microscopic Colitis
Variations in the occurrence of microscopic colitis among different ethnic groups may provide insights into its etiology. The aim of our study was to utilize a large electronic database of…
The Yield of Colonic Biopsy in the Evaluation of Chronic Unexplained Diarrhea
Diarrhea is a common symptom of patients with infectious, inflammatory and systemic diseases presenting with gastrointestinal manifestations. Colonoscopy with biopsy is widely used for the evaluation of diarrhea (often defined…
Low Prevalence of Eosinophilic Esophagitis in Hispanics and Asians in the United States
National differences in the prevalence of eosinophilic esophagitis (EoE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
