Categorized: Abstracts & Presentations, Gastroenterology

Correlation of P16 Expression and Clinicopathologic Outcome of Anal Squamous Cell Carcinoma

Anal squamous cell carcinoma (ASCC) is uncommon, and accounts for 4% of carcinomas involving the gastrointestinal tract. The pathogenesis of ASCC is still unknown. Many studies have shown a strong association of anal squamous cell carcinoma with human papilloma virus (HPV). In multiple studies, over expression of P16(INK4a) by immunohistochemistry (IHC) was noted in HPV-related anal, cervical and upper aerodigestive squamous cell carcinoma. These studies showed that IHC for P16 has a high sensitivity and specificity for HPV and suggested that it is a good surrogate marker for identification of HPV-driven tumors. In this study we will identify patients with likely HPV-related ASCC using IHC for P16. We will then compare the clinicopathological and histomorphological features of P16 positive and negative ASCC.

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