Categorized: Abstracts & Presentations, Gastroenterology
DNA Mismatch Repair Deficiency in Inflammatory Bowel Disease Associated Colorectal Carcinomas
Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Compared to sporadic CRC, the molecular pathogenesis of IBD-associated CRC has some distinctive features, particularly the timing of acquisition of genetic changes during progression through high-grade dysplasia. DNA mismatch repair (MMR) deficient sporadic CRC is a well-defined entity comprised of Lynch syndrome-associated cancers and cancers characterized by a CpG island methylator phenotype (CIMP). The latter cancers characteristically arise in sessile serrated adenomas/polyps. The role of MMR deficiency in IBD CRC is less well-established. We undertook this study to determine the frequency and clinical pathologic associations of MMR deficiency in IBD-associated neoplasia.
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