Categorized: Abstracts & Presentations, Gastroenterology

Pathogenetic Differences in the Progression of MLH1 Intact and Deficient Sessile Serrated Adenomas

Sessile serrated adenomas/polyps (SSA) are members of the serrated polyp family, often right sided, and are characterized by wide-bottomed crypts, disordered maturation, and dystrophic goblet cells histologically (Figure 1). SSAs frequently progress to cancer via MLH1 methylation silencing and the acquisition of DNA mismatch repair deficiency. Little is known about clinical or pathogenetic differences between MLH1 intact and MLH1 deficient lesions.

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