Categorized: Abstracts & Presentations, Gastroenterology

Recognition of the null staining pattern increases the utility of p53 IHC in Barrett’s esophagus

Mutation and/or deletion of p53, a cell cycle regulatory gene, is a promising biomarker for predicting the risk of neoplastic progression in Barrett’s esophagus (BE). Although overexpression of p53 by immunohistochemistry (IHC) is a useful surrogate for point mutations, complete absence of p53 protein by IHC in neoplastic cells (null pattern) has recently been shown to be highly correlated with truncation and deletion mutations. This study was designed to evaluate p53 expression patterns in BE with and without dysplasia.

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