Scientific Publications
Recent publications in Gastroenterology
Inform Diagnostics fosters an academic environment where ongoing research and education are encouraged. Read the latest abstracts, articles, and publications from the GI pathologists at Inform Diagnostics.
Low-grade Dysplasia in Barrett’s Esophagus: A Difficult Diagnosis Best Handled by Experts
Low-grade dysplasia in Barrett’s esophagus is overdiagnosed. Studies have shown that Barrett’s mucosa with low-grade dysplasia is significantly over-diagnosed.1 In one study, 12.2% of Barrett’s patients were diagnosed with low-grade…
Failure to follow biopsy guidelines may contribute to the under-diagnosis of celiac disease in the United States
When faced with a patient with possible celiac disease, a physician has the option to conduct several tests, including a blood test to look for gluten antibodies and nutritional deficiencies,…
Spare the H. pylori and spoil the esophagus?
Eosinophilic esophagitis (EoE) is a condition that causes swallowing problems, particularly in younger patients. EoE, which is believed to result from allergic processes, has dramatically increased in frequency in the…
The Mismatch Repair Gene Mutation Screening Program for Lynch Syndrome: Identifying Patients at Risk
The Inform Diagnostics DNA mismatch repair (MMR) gene mutation screening program for Lynch Syndrome was initiated in March 2010, with the objective of testing not only all newly diagnosed colorectal…
Focal Active Colitis: What does this histologic pattern mean clinically?
Focal active colitis (FAC) is a histologic pattern of injury, not a specific diagnosis. From a morphologic standpoint, FAC is defined either as a single focus of neutrophilic crypt injury…
Eosinophilic Esophagitis is Associated with an Increased Prevalence of Inflammatory Bowel Disease
Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic disease thought to arise from an allergy/immune-mediated process. Reports of patients with EoE and concurrent inflammatory bowel disease (IBD) have suggested that…
Unexpected Candidiasis in the Endoscopically Normal Esophagus
We identified several cases in which a histopathologic diagnosis of Candida esophagitis was made in a patient with no known risk factors and an esophagus specifically described as endoscopically normal.…
Intestinal Spirochetosis is Associated with Diarrhea, Weight Loss and Abdominal Pain: A Study of 447 Patients and 1.2 Million Controls
Intestinal spirochetosis is a condition in which the colonic mucosa is colonized by anaerobic spirochetes, either Brachyspira aalborgi or Brachyspira pilosicoli. Intestinal spirochetosis is generally associated with immunocompromised states such…
Low Prevalence of Colon Polyps in Patients with Diarrhea and Microscopic Colitis
Microscopic colitis (MC) is a condition that includes a spectrum of histological abnormalities of the colonic mucosa, ranging from an increase in the number of intraepithelial lymphocytes (IELs) (‘‘lymphocytic colitis’’,…
Gastric Pathology in HIV-Infected Patients
Thirty years after its discovery, Helicobacter pylori remains the world’s most common infectious agent, with an estimated prevalence ranging from less than 5% in Northern European children to more than…
Proton Pump Inhibitor Use in Patients with Helicobacter Gastritis is Associated with a High Prevalence of Corpus-Predominant Gastritis and Intestinal Metaplasia
European studies have shown that long-term proton-pump inhibitor (PPI) therapy in patients with GERD and antrum-predominant (AP) gastritis may induce a proximal shift of both bacteria and inflammation, resulting in…
Recognition of the null staining pattern increases the utility of p53 IHC in Barrett’s esophagus
Mutation and/or deletion of p53, a cell cycle regulatory gene, is a promising biomarker for predicting the risk of neoplastic progression in Barrett’s esophagus (BE). Although overexpression of p53 by…
Differences and Similarities in the Epidemiology of Lymphocytic and Collagenous Colitis
It is unknown whether the subtypes of microscopic colitis represent distinct nosologic entities or related presentations of the same disease. Our aim was to search for epidemiologic differences and similarities…
Hyperplastic Polyps Predict the Subsequent Occurrence of Adenomatous Polyps on Follow-up Colonoscopy
The occurrence of hyperplastic polyps during colonoscopy is usually considered an incidental finding of little or no clinical significance. We pursued the hypothesis that diagnosis of hyperplastic polyps on index…
Low Prevalence of H. pylori Infection in Patients with Gastroparesis
Gastroparesis is a condition characterized by gastric retention in the absence of physical obstruction. As part of an ongoing project aimed at determining the pathogenesis of reactive gastropathy, we hypothesized…
DNA Mismatch Repair Deficiency in Inflammatory Bowel Disease Associated Colorectal Carcinomas
Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Compared to sporadic CRC, the molecular pathogenesis of IBD-associated CRC has some distinctive features, particularly…
Gastroduodenal Pathology in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). Traditionally, CD is thought to involve the entire gastrointestinal tract in a patchy manner. UC involves the colon…
Granular Cell Tumors of the Gastrointestinal Tract: Clinicopathologic Associations in a Large Series
We designed this study to use a large national pathology database to better characterize the demographic and clinicopathologic features of granular cell tumors (GCT) of the gastrointestinal tract. Because these…
Lymphocytic Gastritis: A Distinct Nosologic Entity or A Histopathologic Expression of Other Conditions?
Lymphocytic gastritis (LG) is characterized by infiltration of the gastric foveolar epithelium by at least 25 lymphocytes per 100 epithelial cells, regardless of the inflammation in the lamina propria.1 This…
Polyps with Advanced Neoplasia are Smaller in the Right than in the Left Colon: Implications for Colorectal Cancer Screening
Published in Clinical Gastroenterology and Hepatology, July 25, 2012 Samir Gupta, MD, Bijal A. Balasubramanian, MBBS, PhD, Tommy Fu, MD, MBA, Robert M. Genta, MD, Don C. Rockey, MD, and…
