Scientific Publications
Recent abstracts and presentations
As part of fostering an academic environment, our pathologists present their research in peer-reviewed journals and at internationally attended conferences.
High Prevalence of Ulcerative Colitis in US Residents of Indian Origin
The prevalence of Inflammatory bowel disease (IBD), including both Crohn Disease (CD) and ulcerative colitis (UC) is reportedly high in Ashkenazi Jews, but it is believed to be very low…
The Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the United States Parallels the Incidence of Gastric Cancer in Their Corresponding Ancestral Countries
The epidemiology of H. pylori infection and the incidence of gastric cancer (GC) and its precursor lesions in different countries are well established. However, the consequences of such variability for…
Low Prevalence of Microscopic Colitis and Inflammatory Bowel Disease in Americans of East Asian Ancestry
East Asian countries have historically reported low incidences of microscopic colitis and inflammatory bowel disease (1); however, it is unclear whether these data reflect genetic or environmental factors or are…
Ethnic Distribution of Atrophic Autoimmune Gastritis in the United States
Autoimmune Atrophic Gastritis (AIG) has classically been associated with “elderly women of Northern European ancestry.” (Friedlander, Am. J. Med. Sci,1934) Several epidemiologic studies have shown equal prevalence in various ethnic…
Gastric Antral Vascular Ectasia: The Invaluable Role of the Gastric Biopsy in its Detection and Confirmation
Gastric vasculopathies consist predominantly of two entities: Gastric antral vascular ectasia (GAVE)Portal hypertensive gastropathy (PHG) The classically described GAVE patient is an elderly woman with iron-deficiency anemia and a “watermelon”…
Gastric Polyps: Shifting Paradigms in the Twilight of Helicobacter
H. pylori infection is declining in the industrialized world and emerging economies. Simultaneously, as the world population moves to a “Western” diet, obesity and gastroesophageal reflux disease are on the…
Correlation of P16 Expression and Clinicopathologic Outcome of Anal Squamous Cell Carcinoma
Anal squamous cell carcinoma (ASCC) is uncommon, and accounts for 4% of carcinomas involving the gastrointestinal tract. The pathogenesis of ASCC is still unknown. Many studies have shown a strong…
Submucosal Lipoma and Sessile Serrated Adenoma/Polyp, More Than Just a Coincidence?
In our practice we noticed that sessile serrated adenomas/polyps (SSA/P) were frequently associated with submucosal lipomas (SL). While this finding has been reported by other experts, it is unclear if…
Isolated Eosinophilic Colitis: A Challenging Diagnosis in Search of Criteria
Eosinophils infiltrate the colonic mucosa in response to tissue-invading parasites, as part of eosinophilic gastroenteritis (EoG), or as an isolated presumably allergic phenomenon. Focal infiltrates around parasite fragments are easily…
Heterogeneity of PTEN and ERG Biomarkers Expression in Prostate Cancer Needle Biopsies with More Than One Core Positive: Implications for Biomarkers Sampling Strategy
Both PTEN and ERG biomarkers demonstrate significant inter- and intra-tumor core staining heterogeneity, suggesting that sampling may affect biomarkers interpretation. View the poster
Helicobacter-negative Chronic Active Gastritis is an Independent Nosologic Entity, Not Merely Missed Helicobacter Infection: A Nationwide Study of 600,000 Patients
Helicobacter-negative chronic active gastritis is a histopathologic entity characterized by diffuse chronic active inflammation in a pattern typically encountered in H. pylori gastritis, but with no organisms detectable by conventional…
Esophageal Eosinophilia and Gastric Mucosal Pathology: Is There a Link?
We have previously reported, and others have confirmed, an inverse relationship between eosinophilic esophagitis and Helicobacter pylori gastritis. Other conditions affecting the stomach can include reactive gastropathy, autoimmune atrophic gastritis,…
Anal Canal Syphilis: A Challenging Diagnosis for the Gastrointestinal Pathologist
The rates of primary and secondary syphilis have been increasing in the United States since 2001, following a historic low in 2000. The manifestations of syphilis as a genital disease…
Eosinophilic Esophagitis is Associated with an Increased Prevalence of Inflammatory Bowel Disease
Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic disease thought to arise from an allergy/immune-mediated process. Reports of patients with EoE and concurrent inflammatory bowel disease (IBD) have suggested that…
Unexpected Candidiasis in the Endoscopically Normal Esophagus
We identified several cases in which a histopathologic diagnosis of Candida esophagitis was made in a patient with no known risk factors and an esophagus specifically described as endoscopically normal.…
Intestinal Spirochetosis is Associated with Diarrhea, Weight Loss and Abdominal Pain: A Study of 447 Patients and 1.2 Million Controls
Intestinal spirochetosis is a condition in which the colonic mucosa is colonized by anaerobic spirochetes, either Brachyspira aalborgi or Brachyspira pilosicoli. Intestinal spirochetosis is generally associated with immunocompromised states such…
Low Prevalence of Colon Polyps in Patients with Diarrhea and Microscopic Colitis
Microscopic colitis (MC) is a condition that includes a spectrum of histological abnormalities of the colonic mucosa, ranging from an increase in the number of intraepithelial lymphocytes (IELs) (‘‘lymphocytic colitis’’,…
Gastric Pathology in HIV-Infected Patients
Thirty years after its discovery, Helicobacter pylori remains the world’s most common infectious agent, with an estimated prevalence ranging from less than 5% in Northern European children to more than…
Proton Pump Inhibitor Use in Patients with Helicobacter Gastritis is Associated with a High Prevalence of Corpus-Predominant Gastritis and Intestinal Metaplasia
European studies have shown that long-term proton-pump inhibitor (PPI) therapy in patients with GERD and antrum-predominant (AP) gastritis may induce a proximal shift of both bacteria and inflammation, resulting in…
Recognition of the null staining pattern increases the utility of p53 IHC in Barrett’s esophagus
Mutation and/or deletion of p53, a cell cycle regulatory gene, is a promising biomarker for predicting the risk of neoplastic progression in Barrett’s esophagus (BE). Although overexpression of p53 by…
