Scientific Publications
Recent abstracts and presentations
As part of fostering an academic environment, our pathologists present their research in peer-reviewed journals and at internationally attended conferences.
Plasma Cell Enrichment: A Valuable Tool to Increase Abnormality Detection Rates in Plasma Cell Disorders by FISH
E. Kroman, L. Scott, Q. Zhao, J. Zhang, T. Golding, M.L. Miller, W.L. Flejter – Inform Diagnostics Cytogenetic analysis of plasma cell disorders (PCD) is difficult owing to their low…
Xanthomatous Lichen Planus-Like Keratosis: An Emerging Clinical Entity?
Lichen planus-like keratosis (LPLK) was first described in 1966 as a lesion that is clinically distinct from lichen planus (LP) but histologically indistinguishable from LP. Clinically, LPLK appears different from…
A Case of Granulomatous Dermatitis Occurring After Implantation of a Titanium-Containing Pacemaker
Granulomatous contact dermatitis to metals, including titanium-containing pacemakers, is rare but has been documented in the literature. The pathogenesis is likely to be a delayed hypersensitivityreaction to the metal. We…
Multicolor Flow Cytometry Detects Monoclonal Plasma Cells in the Vast Majority of Patients with Plasma Cell Disorders Shown to Have Genetic Abnormalities by Fluorescence In Situ Hybridization (FISH)
Raul Braylan, Karina Baggiani, Tiana Golding, Eric Kroman, Michael L. Miller, and Wendy L. Flejter The flow cytometric analysis is considered an essential tool for the identification of malignant hemopoietic…
The Importance of Lymphoid Stimulation and FISH to Detect Complex Translocations in Oncology
K. Stiner, N. Lee, K. Abdi, L. White, L. Dean, Q. Virgo, W.L. Flejter PhD A bone marrow sample was received from a forty-five year old female with submandibular lymphadenopathy…
Signet Ring Cell Carcinoma of the Esophagus
Signet ring cell carcinoma is a histologic variant of adenocarcinoma characterized by a population of loose tumor cells whose cytoplasm appears almost entirely occupied by mucin. In rare instances, signet…
Demographic and Socio-economic Influences on H. pylori-induced Changes to the Gastric Mucosa
Over a lifetime, gastric infection with Helicobacter pylori (Hp) can lead to chronic active gastritis (CAG), chronic inactive gastritis (CIG), intestinal metaplasia (IM) and atrophy (ATR). Little is known whether…
The Endoscopically Normal Stomach: Is It Worth a Biopsy?
In the absence of endoscopically visible lesions (such as tumors or ulcers), the gross appearance of the gastric mucosa is not believed by some gastroenterologists to be a reliable predictor…
Helicobacter pylori Gastritis: Atypical Infections May Be Missed Without the Regular Use of Special Stains
In most patients, Helicobacter pylori infection causes chronic active gastritis, a pattern that prompts pathologists to search for organisms, including the use of special or immunohistochemical stains. As a consequence…
Low Prevalence of Villous Atrophy (Marsh 3) in Duodenal Biopsies from Americans of East Asian and Hispanic Ancestry and High Prevalence in Northern Indians
East Asian countries have historically reported low prevalences of celiac disease (CD). Data from Latin America are more varied, but rates similar to those found in Europe and the United…
Pathogenetic Differences in the Progression of MLH1 Intact and Deficient Sessile Serrated Adenomas
Sessile serrated adenomas/polyps (SSA) are members of the serrated polyp family, often right sided, and are characterized by wide-bottomed crypts, disordered maturation, and dystrophic goblet cells histologically (Figure 1). SSAs…
Subepithelial Fibrosis is a Distinctive Characteristic of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic, allergy-related disease in which prolonged eosinophil-predominant inflammation can cause tissue remodeling. The remodeling results in serious complications including esophageal rings, strictures, and mucosal fragility,…
Intestinal Metaplasia of the Inlet Patch: Clinical and Pathological Associations
Heterotopic gastric mucosa (HGM) located in the proximal esophagus is referred to as “inlet patch.” Although its prevalence is reported to be around 4%, the inlet patch is infrequently biopsied.…
Granulomas in Crohn’s Disease are Associated With More Severe Disease Expression
The relevance of granulomas in the histopathology of patients with Crohn’s disease is largely unknown. Most previous studies have relied on small case series. The aim of our study was…
Ethnic Distribution of Microscopic Colitis
Variations in the occurrence of microscopic colitis among different ethnic groups may provide insights into its etiology. The aim of our study was to utilize a large electronic database of…
The Yield of Colonic Biopsy in the Evaluation of Chronic Unexplained Diarrhea
Diarrhea is a common symptom of patients with infectious, inflammatory and systemic diseases presenting with gastrointestinal manifestations. Colonoscopy with biopsy is widely used for the evaluation of diarrhea (often defined…
Incidence and Clinicopathological Characteristics of Gleason Pattern 5 Prostate Cancer in Contemporary Needle Biopsies Series: A Prospective Study
Management of patients with prostate adenocarcinoma (PCa) heavily depends on the Gleason score assigned on prostate needle biopsy (NBX). The presence of a Gleason pattern 5 (GP5) PCa is associated…
Low Prevalence of Eosinophilic Esophagitis in Hispanics and Asians in the United States
National differences in the prevalence of eosinophilic esophagitis (EoE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
Barrett’s Esophagus is Not Rare in Asian Patients Who Have Esophageal Biopsies Taken in the United States
National differences in the prevalence of Barrett’s esophagus (BE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
Influence of Patients’ Ethnicity on the Gastric Biopsy Sampling Patterns
Although the Sydney System protocol requires separate biopsy sampling from antrum, incisura, and corpus, less than 4% of U.S. endoscopists adhere to these recommendations. There are significant differences in the…
