Scientific Publications
Recent publications in Urology
At Inform Diagnostics, our uropathologists see more cases per year than the average uropathologist. In addition, we encourage ongoing research and education and are proud of the peer-reviewed research our uropathologists have published. Read their latest research below, including pioneering work in areas such as atypical intraductal proliferation and intraductal carcinoma of prostate (IDC-P).
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists
Shah RB, Li J, Cheng L, Tian W, Yang XJ, Zhou M, and others Poster presentation given to the United States and Canadian Academy of Pathology’s 2015 Annual Meeting in Boston, MA. For…
Fluorescence in-situ hybridization in urine samples: a study of 69 cases with emphasis on clinicopathological features and outcome
Tian W, Kroman E, Flejter WL, and Shah RB Poster presentation given to the United States and Canadian Academy of Pathology’s 2016 Annual Meeting in Seattle, WA. For a copy, please contact Inform Diagnostics.
High-grade prostatic intraepithelial neoplasia with adjacent small atypical glands (PINATYP) on core needle biopsy: a clinicopathological analysis of 53 cases with emphasis on predictors of prostate cancer
Shah RB, Tian W, and Zhou M Poster presentation given to the United States and Canadian Academy of Pathology’s 2016 Annual Meeting in Seattle, WA. For a copy, please contact Inform Diagnostics.
Urine cytology diagnostic patterns before and after implementing the Paris system for reporting urine cytology: a large single institutional study of over 27,000 cases
Tian W, Shore KT, and Shah RB Poster presentation give to the United States and Canadian Academy of Pathology’s 2020 Annual Meeting in Los Angeles, CA. For a copy, please contact Inform…
The utilization of the Prolaris® test and its correlation with AUA risk groups and pathological features for over 500 patients diagnosed with prostate cancer in a community practice
Tian W, Shore KT, Jiyoon Yoon, and Shah RB Poster presentation given to the United States and Canadian Academy of Pathology’s 2019 Annual Meeting in National Harbor, MD. For a copy, please contact Inform…
Morphological correlates of PTE tumor suppressor gene loss in prostate cancer
Shah RB, Shore KT, Yoon J, Tian W and Mendrinos S Poster presentation given to the United States and Canadian Academy of Pathology’s 2018 Annual Meeting in Vancouver, BC, Canada. For a copy, please contact Inform Diagnostics.
Diagnosis of limited prostate adenocarcinoma on core needle biopsy: an improvement of interobserver reproducibility using comprehensive morphological and molecular criteria
Shah RB, Tian W, and others Poster presentation given to the United States and Canadian Academy of Pathology’s 2016 Annual Meeting in Seattle, WA. For a copy, please contact Inform Diagnostics.
Urine cytology diagnostic patterns before and after implementing the Paris system for reporting urine cytology: a large single institutional study of over 27,000 cases
Tian W, Shore KT, and Shah RB Podium presentation given to the American Urological Association’s 2020 Annual Meeting in Washington, D.C. For a copy, please contact Inform Diagnostics.
The diagnostic use of ERG in resolving an “atypical glands suspicious for cancer” diagnosis in prostate biopsies beyond that provided by basal cell and α-methylacyl-CoA-racemase markers.
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen in ~50% of prostate carcinomas (PCas) and ~20% of high-grade…
Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: Impact of mandatory central pathology review at a large referral hospital
Urothelial carcinoma (UC) has peculiar capacity to undergo variant or divergent histological differentiation into a gamut of different histology types. UC demonstrating variant histological differentiation is associated with poor outcomes,…
p63, CK7, PAX8, and INI-1: An optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
High-grade, poorly differentiated, infiltrative carcinomas involving the renal sinus region often pose challenging differential diagnostic considerations, specifically differentiation of urothelial carcinoma (UC) from renal cell carcinoma (RCC) subtypes. Accurate diagnosis…
Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.
Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” (IDC-P). IDC-P is almost always associated with clinically aggressive high-volume…
ERG overexpression and multifocality predict prostate cancer in subsequent biopsy for patients with high-grade prostatic intraepithelial neoplasia
Accepted to Urologic Oncology, 2015. Authors: Rajal B. Shah, M.D., Jianbo Li, Ph.D., Nadeem Dhanani, M.D., Savvas Mendrinos, M.D. The most important clinical significance of an isolated high-grade prostatic intraepithelial…
Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and Management
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen in ~50% of prostate carcinomas (PCas) and ~20% of high-grade…
Carcinoma of the Collecting Ducts of Bellini and Renal Medullary Carcinoma: Clinicopathologic Analysis of 52 Cases of Rare Aggressive Subtypes of Renal Cell Carcinoma With a Focus on Their Interrelationship
Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma are rare aggressive renal tumors. First described in 1949, case reports and review articles constitute a major source of…
Predictive Value of ERG Oncoprotein Expression and Pathologic Parameters In the Stratification of Prostate Cancer Risk Associated With High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Diagnosis In Prostate Needle Biopsy
This research was presented at the AUA annual conference in May 2015, in New Orleans. High-grade prostatic intraepithelial neoplasia (HGPIN) is a putative neoplastic precursor lesion of prostate cancer (PCa).…
PTEN Protein Loss and Genomic Deletions in Prostate Cancer: A Comparative Study of Immunohistochemistry and Four-Color FISH Assay
PTEN (phosphatase and tensing homolog) on chromosome 10q23 is a key tumor suppressor gene that is deleted or inactivated in 30-40% of clinically localized prostate cancers (PCa) and is frequently…
Incidence and Clinicopathological Characteristics of Gleason Pattern 5 Prostate Cancer in Contemporary Needle Biopsies Series: A Prospective Study
Management of patients with prostate adenocarcinoma (PCa) heavily depends on the Gleason score assigned on prostate needle biopsy (NBX). The presence of a Gleason pattern 5 (GP5) PCa is associated…
Heterogeneity of PTEN and ERG Biomarkers Expression in Prostate Cancer Needle Biopsies with More Than One Core Positive: Implications for Biomarkers Sampling Strategy
Both PTEN and ERG biomarkers demonstrate significant inter- and intra-tumor core staining heterogeneity, suggesting that sampling may affect biomarkers interpretation. View the poster
Anal Canal Syphilis: A Challenging Diagnosis for the Gastrointestinal Pathologist
The rates of primary and secondary syphilis have been increasing in the United States since 2001, following a historic low in 2000. The manifestations of syphilis as a genital disease…
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