Scientific Publications
Recent publications, abstracts, and presentations
Our fellowship-trained pathologists actively participate in research initiatives and present their work at internationally attended conferences. See their latest work in their areas of subspecialty expertise.
The diagnostic use of ERG in resolving an “atypical glands suspicious for cancer” diagnosis in prostate biopsies beyond that provided by basal cell and α-methylacyl-CoA-racemase markers.
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen in ~50% of prostate carcinomas (PCas) and ~20% of high-grade…
Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: Impact of mandatory central pathology review at a large referral hospital
Urothelial carcinoma (UC) has peculiar capacity to undergo variant or divergent histological differentiation into a gamut of different histology types. UC demonstrating variant histological differentiation is associated with poor outcomes,…
p63, CK7, PAX8, and INI-1: An optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
High-grade, poorly differentiated, infiltrative carcinomas involving the renal sinus region often pose challenging differential diagnostic considerations, specifically differentiation of urothelial carcinoma (UC) from renal cell carcinoma (RCC) subtypes. Accurate diagnosis…
Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.
Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” (IDC-P). IDC-P is almost always associated with clinically aggressive high-volume…
Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes
Published in May 2016 by JAMA The Journal of the American Medical Association. Authors: Kerry B. Dunbar, MD, PhD; Agoston T. Agoston, MD, PhD; Robert D. Odze, MD; Xiaofang Huo,…
Healthcare Cost of Over-Diagnosis of Low-Grade Dysplasia in Barrett’s Esophagus
Published online by Advances in Therapy, 2016. Authors: Richard H. Lash, Thomas M. Deas, Jr., Frank H. Wians, Jr. Published reports have demonstrated that many Barrett’s esophagus patients are over-diagnosed…
Geographic Distributions of Microscopic Colitis and Inflammatory Bowel Disease in the United States
Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by similar geographic distributions. We used a large database of pathology reports to analyze the geographic distribution of microscopic colitis (MC)…
Inverse Association of Esophageal Eosinophilia With Helicobacter pylori Based on Analysis of a US Pathology Database
Evan S. Dellon, Anne F. Peery, Nicholas J. Shaheen, Douglas R. Morgan, Jennifer M. Hurrell, Richard H. Lash, Robert M. Genta Published in Gastroenterology, 2011. Eosinophilic esophagitis (EoE) is of…
ERG overexpression and multifocality predict prostate cancer in subsequent biopsy for patients with high-grade prostatic intraepithelial neoplasia
Accepted to Urologic Oncology, 2015. Authors: Rajal B. Shah, M.D., Jianbo Li, Ph.D., Nadeem Dhanani, M.D., Savvas Mendrinos, M.D. The most important clinical significance of an isolated high-grade prostatic intraepithelial…
Lymphocytic oesophagitis: clinicopathological aspects of an emerging condition
Salima Haque, Robert M. Genta Published in Gut, 2012 Lymphocytic oesophagitis (LyE) has been reported in small series, but no consistent clinical correlations have emerged. The authors sought to determine…
Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups
Robert C. Kapel, Jocelyne K. Miller, Carlos Torres, Saime Aksoy, Richard Lash, And David A. Katzka Published in Gastroenterology, 2008 Most reports on eosinophilic esophagitis (EE) are limited to small…
Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and Management
Immunohistochemical (IHC) staining for ERG is utilized as a surrogate for TMPRSS2: ERG gene fusions, a specific molecular event seen in ~50% of prostate carcinomas (PCas) and ~20% of high-grade…
Carcinoma of the Collecting Ducts of Bellini and Renal Medullary Carcinoma: Clinicopathologic Analysis of 52 Cases of Rare Aggressive Subtypes of Renal Cell Carcinoma With a Focus on Their Interrelationship
Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma are rare aggressive renal tumors. First described in 1949, case reports and review articles constitute a major source of…
Predictive Value of ERG Oncoprotein Expression and Pathologic Parameters In the Stratification of Prostate Cancer Risk Associated With High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Diagnosis In Prostate Needle Biopsy
This research was presented at the AUA annual conference in May 2015, in New Orleans. High-grade prostatic intraepithelial neoplasia (HGPIN) is a putative neoplastic precursor lesion of prostate cancer (PCa).…
Signet Ring Cell Carcinoma of the Esophagus
Signet ring cell carcinoma is a histologic variant of adenocarcinoma characterized by a population of loose tumor cells whose cytoplasm appears almost entirely occupied by mucin. In rare instances, signet…
PTEN Protein Loss and Genomic Deletions in Prostate Cancer: A Comparative Study of Immunohistochemistry and Four-Color FISH Assay
PTEN (phosphatase and tensing homolog) on chromosome 10q23 is a key tumor suppressor gene that is deleted or inactivated in 30-40% of clinically localized prostate cancers (PCa) and is frequently…
Demographic and Socio-economic Influences on H. pylori-induced Changes to the Gastric Mucosa
Over a lifetime, gastric infection with Helicobacter pylori (Hp) can lead to chronic active gastritis (CAG), chronic inactive gastritis (CIG), intestinal metaplasia (IM) and atrophy (ATR). Little is known whether…
The Endoscopically Normal Stomach: Is It Worth a Biopsy?
In the absence of endoscopically visible lesions (such as tumors or ulcers), the gross appearance of the gastric mucosa is not believed by some gastroenterologists to be a reliable predictor…
Helicobacter pylori Gastritis: Atypical Infections May Be Missed Without the Regular Use of Special Stains
In most patients, Helicobacter pylori infection causes chronic active gastritis, a pattern that prompts pathologists to search for organisms, including the use of special or immunohistochemical stains. As a consequence…
Low Prevalence of Villous Atrophy (Marsh 3) in Duodenal Biopsies from Americans of East Asian and Hispanic Ancestry and High Prevalence in Northern Indians
East Asian countries have historically reported low prevalences of celiac disease (CD). Data from Latin America are more varied, but rates similar to those found in Europe and the United…
