Scientific Publications
Recent publications, abstracts, and presentations
Our fellowship-trained pathologists actively participate in research initiatives and present their work at internationally attended conferences. See their latest work in their areas of subspecialty expertise.
Pathogenetic Differences in the Progression of MLH1 Intact and Deficient Sessile Serrated Adenomas
Sessile serrated adenomas/polyps (SSA) are members of the serrated polyp family, often right sided, and are characterized by wide-bottomed crypts, disordered maturation, and dystrophic goblet cells histologically (Figure 1). SSAs…
Subepithelial Fibrosis is a Distinctive Characteristic of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic, allergy-related disease in which prolonged eosinophil-predominant inflammation can cause tissue remodeling. The remodeling results in serious complications including esophageal rings, strictures, and mucosal fragility,…
Intestinal Metaplasia of the Inlet Patch: Clinical and Pathological Associations
Heterotopic gastric mucosa (HGM) located in the proximal esophagus is referred to as “inlet patch.” Although its prevalence is reported to be around 4%, the inlet patch is infrequently biopsied.…
Granulomas in Crohn’s Disease are Associated With More Severe Disease Expression
The relevance of granulomas in the histopathology of patients with Crohn’s disease is largely unknown. Most previous studies have relied on small case series. The aim of our study was…
Ethnic Distribution of Microscopic Colitis
Variations in the occurrence of microscopic colitis among different ethnic groups may provide insights into its etiology. The aim of our study was to utilize a large electronic database of…
The Yield of Colonic Biopsy in the Evaluation of Chronic Unexplained Diarrhea
Diarrhea is a common symptom of patients with infectious, inflammatory and systemic diseases presenting with gastrointestinal manifestations. Colonoscopy with biopsy is widely used for the evaluation of diarrhea (often defined…
Incidence and Clinicopathological Characteristics of Gleason Pattern 5 Prostate Cancer in Contemporary Needle Biopsies Series: A Prospective Study
Management of patients with prostate adenocarcinoma (PCa) heavily depends on the Gleason score assigned on prostate needle biopsy (NBX). The presence of a Gleason pattern 5 (GP5) PCa is associated…
Low Prevalence of Eosinophilic Esophagitis in Hispanics and Asians in the United States
National differences in the prevalence of eosinophilic esophagitis (EoE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
Barrett’s Esophagus is Not Rare in Asian Patients Who Have Esophageal Biopsies Taken in the United States
National differences in the prevalence of Barrett’s esophagus (BE) have been described, but it is not clear whether these differences are real (due to differences in genetic or environmental factors)…
Influence of Patients’ Ethnicity on the Gastric Biopsy Sampling Patterns
Although the Sydney System protocol requires separate biopsy sampling from antrum, incisura, and corpus, less than 4% of U.S. endoscopists adhere to these recommendations. There are significant differences in the…
High Prevalence of Ulcerative Colitis in US Residents of Indian Origin
The prevalence of Inflammatory bowel disease (IBD), including both Crohn Disease (CD) and ulcerative colitis (UC) is reportedly high in Ashkenazi Jews, but it is believed to be very low…
The Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the United States Parallels the Incidence of Gastric Cancer in Their Corresponding Ancestral Countries
The epidemiology of H. pylori infection and the incidence of gastric cancer (GC) and its precursor lesions in different countries are well established. However, the consequences of such variability for…
Low Prevalence of Microscopic Colitis and Inflammatory Bowel Disease in Americans of East Asian Ancestry
East Asian countries have historically reported low incidences of microscopic colitis and inflammatory bowel disease (1); however, it is unclear whether these data reflect genetic or environmental factors or are…
Ethnic Distribution of Atrophic Autoimmune Gastritis in the United States
Autoimmune Atrophic Gastritis (AIG) has classically been associated with “elderly women of Northern European ancestry.” (Friedlander, Am. J. Med. Sci,1934) Several epidemiologic studies have shown equal prevalence in various ethnic…
Gastric Antral Vascular Ectasia: The Invaluable Role of the Gastric Biopsy in its Detection and Confirmation
Gastric vasculopathies consist predominantly of two entities: Gastric antral vascular ectasia (GAVE)Portal hypertensive gastropathy (PHG) The classically described GAVE patient is an elderly woman with iron-deficiency anemia and a “watermelon”…
Gastric Polyps: Shifting Paradigms in the Twilight of Helicobacter
H. pylori infection is declining in the industrialized world and emerging economies. Simultaneously, as the world population moves to a “Western” diet, obesity and gastroesophageal reflux disease are on the…
Correlation of P16 Expression and Clinicopathologic Outcome of Anal Squamous Cell Carcinoma
Anal squamous cell carcinoma (ASCC) is uncommon, and accounts for 4% of carcinomas involving the gastrointestinal tract. The pathogenesis of ASCC is still unknown. Many studies have shown a strong…
Submucosal Lipoma and Sessile Serrated Adenoma/Polyp, More Than Just a Coincidence?
In our practice we noticed that sessile serrated adenomas/polyps (SSA/P) were frequently associated with submucosal lipomas (SL). While this finding has been reported by other experts, it is unclear if…
Isolated Eosinophilic Colitis: A Challenging Diagnosis in Search of Criteria
Eosinophils infiltrate the colonic mucosa in response to tissue-invading parasites, as part of eosinophilic gastroenteritis (EoG), or as an isolated presumably allergic phenomenon. Focal infiltrates around parasite fragments are easily…
Gastric Antral Vascular Ectasia: Relevance of the Histopathologic Diagnosis
Gastric Antral Vascular Ectasia (GAVE) is traditionally considered an endoscopic diagnosis. Because the role of the gastric biopsy is uncertain, and the relatively obscure criteria proposed by Gilliam (Dig Dis…
