Scientific Publications
Recent publications, abstracts, and presentations
Our fellowship-trained pathologists actively participate in research initiatives and present their work at internationally attended conferences. See their latest work in their areas of subspecialty expertise.
Duodenal Adenomas Coincide with Colorectal Neoplasia
Published by Digestive Diseases and Sciences, April 6, 2014 Robert M. Genta, MD, Jennifer M. Hurrell, DO, Amnon Sonnenberg, MD, MSc Small case series have alluded to an association between…
Heterogeneity of PTEN and ERG Biomarkers Expression in Prostate Cancer Needle Biopsies with More Than One Core Positive: Implications for Biomarkers Sampling Strategy
Both PTEN and ERG biomarkers demonstrate significant inter- and intra-tumor core staining heterogeneity, suggesting that sampling may affect biomarkers interpretation. View the poster
Help us help you! A Practical Approach to Biopsying the GI Tract (Part 2)
Part 2 — Lower GI tract See Part 1 — Upper GI tract Optimal biopsy sampling will help your expert Inform Diagnostics GI pathologist to render a specific and accurate…
Help us help you! A Practical Approach to Biopsying the GI Tract (Part 1)
Part 1—Upper GI tract Optimal biopsy sampling will help your expert Inform Diagnostics GI Pathologist to render a specific and accurate diagnosis. In the gastrointestinal tract, it is often important…
The Intradepartmental Consultation: Collaborative Teamwork at its Best
There are many quality-control measures and programs in place at Inform Diagnostics Life Sciences that complement our expertise, ensure the highest quality, and promote the most accurate diagnoses. Among them…
Helicobacter-negative Chronic Active Gastritis is an Independent Nosologic Entity, Not Merely Missed Helicobacter Infection: A Nationwide Study of 600,000 Patients
Helicobacter-negative chronic active gastritis is a histopathologic entity characterized by diffuse chronic active inflammation in a pattern typically encountered in H. pylori gastritis, but with no organisms detectable by conventional…
HER2 Testing: A New Hope for Patients with Gastric and Gastro-Esophageal Adenocarcinoma
Gastric cancer is associated with substantial morbidity and mortality worldwide. It is the second most common cause of cancer-related deaths globally.1 In the United States, the majority of patients with…
Esophageal Eosinophilia and Gastric Mucosal Pathology: Is There a Link?
We have previously reported, and others have confirmed, an inverse relationship between eosinophilic esophagitis and Helicobacter pylori gastritis. Other conditions affecting the stomach can include reactive gastropathy, autoimmune atrophic gastritis,…
Understanding the behavior and progression of sessile serrated adenomas
As pathologists, diagnostic excellence is always our goal. Even so, we are often stymied by differences in terminology, inconsistent application of microscopic criteria and insufficient large-scale studies. These differences make…
Anal Canal Syphilis: A Challenging Diagnosis for the Gastrointestinal Pathologist
The rates of primary and secondary syphilis have been increasing in the United States since 2001, following a historic low in 2000. The manifestations of syphilis as a genital disease…
Low-grade Dysplasia in Barrett’s Esophagus: A Difficult Diagnosis Best Handled by Experts
Low-grade dysplasia in Barrett’s esophagus is overdiagnosed. Studies have shown that Barrett’s mucosa with low-grade dysplasia is significantly over-diagnosed.1 In one study, 12.2% of Barrett’s patients were diagnosed with low-grade…
Failure to follow biopsy guidelines may contribute to the under-diagnosis of celiac disease in the United States
When faced with a patient with possible celiac disease, a physician has the option to conduct several tests, including a blood test to look for gluten antibodies and nutritional deficiencies,…
Spare the H. pylori and spoil the esophagus?
Eosinophilic esophagitis (EoE) is a condition that causes swallowing problems, particularly in younger patients. EoE, which is believed to result from allergic processes, has dramatically increased in frequency in the…
The Mismatch Repair Gene Mutation Screening Program for Lynch Syndrome: Identifying Patients at Risk
The Inform Diagnostics DNA mismatch repair (MMR) gene mutation screening program for Lynch Syndrome was initiated in March 2010, with the objective of testing not only all newly diagnosed colorectal…
Focal Active Colitis: What does this histologic pattern mean clinically?
Focal active colitis (FAC) is a histologic pattern of injury, not a specific diagnosis. From a morphologic standpoint, FAC is defined either as a single focus of neutrophilic crypt injury…
Eosinophilic Esophagitis is Associated with an Increased Prevalence of Inflammatory Bowel Disease
Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic disease thought to arise from an allergy/immune-mediated process. Reports of patients with EoE and concurrent inflammatory bowel disease (IBD) have suggested that…
Unexpected Candidiasis in the Endoscopically Normal Esophagus
We identified several cases in which a histopathologic diagnosis of Candida esophagitis was made in a patient with no known risk factors and an esophagus specifically described as endoscopically normal.…
Intestinal Spirochetosis is Associated with Diarrhea, Weight Loss and Abdominal Pain: A Study of 447 Patients and 1.2 Million Controls
Intestinal spirochetosis is a condition in which the colonic mucosa is colonized by anaerobic spirochetes, either Brachyspira aalborgi or Brachyspira pilosicoli. Intestinal spirochetosis is generally associated with immunocompromised states such…
Low Prevalence of Colon Polyps in Patients with Diarrhea and Microscopic Colitis
Microscopic colitis (MC) is a condition that includes a spectrum of histological abnormalities of the colonic mucosa, ranging from an increase in the number of intraepithelial lymphocytes (IELs) (‘‘lymphocytic colitis’’,…
Gastric Pathology in HIV-Infected Patients
Thirty years after its discovery, Helicobacter pylori remains the world’s most common infectious agent, with an estimated prevalence ranging from less than 5% in Northern European children to more than…
