Scientific Publications
Recent publications, abstracts, and presentations
Our fellowship-trained pathologists actively participate in research initiatives and present their work at internationally attended conferences. See their latest work in their areas of subspecialty expertise.
Proton Pump Inhibitor Use in Patients with Helicobacter Gastritis is Associated with a High Prevalence of Corpus-Predominant Gastritis and Intestinal Metaplasia
European studies have shown that long-term proton-pump inhibitor (PPI) therapy in patients with GERD and antrum-predominant (AP) gastritis may induce a proximal shift of both bacteria and inflammation, resulting in…
Recognition of the null staining pattern increases the utility of p53 IHC in Barrett’s esophagus
Mutation and/or deletion of p53, a cell cycle regulatory gene, is a promising biomarker for predicting the risk of neoplastic progression in Barrett’s esophagus (BE). Although overexpression of p53 by…
Differences and Similarities in the Epidemiology of Lymphocytic and Collagenous Colitis
It is unknown whether the subtypes of microscopic colitis represent distinct nosologic entities or related presentations of the same disease. Our aim was to search for epidemiologic differences and similarities…
Hyperplastic Polyps Predict the Subsequent Occurrence of Adenomatous Polyps on Follow-up Colonoscopy
The occurrence of hyperplastic polyps during colonoscopy is usually considered an incidental finding of little or no clinical significance. We pursued the hypothesis that diagnosis of hyperplastic polyps on index…
Low Prevalence of H. pylori Infection in Patients with Gastroparesis
Gastroparesis is a condition characterized by gastric retention in the absence of physical obstruction. As part of an ongoing project aimed at determining the pathogenesis of reactive gastropathy, we hypothesized…
DNA Mismatch Repair Deficiency in Inflammatory Bowel Disease Associated Colorectal Carcinomas
Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Compared to sporadic CRC, the molecular pathogenesis of IBD-associated CRC has some distinctive features, particularly…
Gastroduodenal Pathology in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). Traditionally, CD is thought to involve the entire gastrointestinal tract in a patchy manner. UC involves the colon…
Granular Cell Tumors of the Gastrointestinal Tract: Clinicopathologic Associations in a Large Series
We designed this study to use a large national pathology database to better characterize the demographic and clinicopathologic features of granular cell tumors (GCT) of the gastrointestinal tract. Because these…
Lymphocytic Gastritis: A Distinct Nosologic Entity or A Histopathologic Expression of Other Conditions?
Lymphocytic gastritis (LG) is characterized by infiltration of the gastric foveolar epithelium by at least 25 lymphocytes per 100 epithelial cells, regardless of the inflammation in the lamina propria.1 This…
Polyps with Advanced Neoplasia are Smaller in the Right than in the Left Colon: Implications for Colorectal Cancer Screening
Published in Clinical Gastroenterology and Hepatology, July 25, 2012 Samir Gupta, MD, Bijal A. Balasubramanian, MBBS, PhD, Tommy Fu, MD, MBA, Robert M. Genta, MD, Don C. Rockey, MD, and…
Atrophic Autoimmune Gastritis: Manifestations and Clinicopathologic Associations in a Large United States Cohort
Atrophic autoimmune gastritis (AIG) is uncommon and most series include few patients. An accurate diagnosis rests on adequate gastric biopsy sampling (rarely done); thus, controls have often been subjects in…
Higher Prevalence of Celiac Disease in the Microscopic Colitis Population: Results From a Large Pathology Database
Microscopic colitis (MC) refers to two medical conditions which cause chronic diarrhea: collagenous colitis (CC) and lymphocytic colitis (LC). Previous studies have reported an increased prevalence of microscopic colitis in…
Epithelial Dysplasia and Cancer in IBD Strictures
The presence of colonic strictures and epithelial dysplasia are both known risk factors for the occurrence of colorectal cancer (CRC) in IBD patients. The aim of the present case-control study…
Same-day Bidirectional Endoscopy: Patients or Practice?
A subset of patients undergo both EGD and colonoscopy on the same day (bidirectional endoscopy or BDE). Although no clear guidelines exist, same-day bidirectional endoscopy has been recommended for patients…
The Aging of the American Stomach: Entering the Post-Helicobacter Era?
Physiologic decline occurs in the stomach of every aging human, but pathologic conditions are affected by genetic and environmental factors. Worldwide, the most important of these is believed to be…
The Cecal Patch is Associated with a Greater Prevalence of Symptoms in Patients with Ulcerative Colitis
The cecal patch is defined as the discontinuous involvement of the cecum in patients with otherwise left-sided ulcerative colitis (UC); see Figures 1 and 2. Several studies have failed to…
Lymphocytic Gastritis: An Expression of Different Diseases
First described by Jules Haot in 1988, lymphocytic gastritis (LG) was initially believed to correspond to an entity mentioned in 1945 by the Belgian gastroenterologist François Moutier, who reported a…
Hepatopathology Services from Inform Diagnostics
While Inform Diagnostics is recognized as a leading provider of academic-caliber GI pathology diagnostic services, did you know about our expertise in hepatopathology? Several pathologists at Inform Diagnostics have extensive…
Recognition of the p53 Null Staining Pattern Increases the Detection of p53 Alterations in Inflammatory Bowel Disease-Associated Carcinomas
Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Mutations in p53 have been found in these cancers, and have been proposed as a…
Clinical and Histologic Spectrum of NSAIDs-Induced Injury in the Right Colon
Non-steroidal anti-inflammatory drugs (NSAIDs) are a significant cause of morbidity and mortality. In the upper gastrointestinal (GI) tract, NSAIDs are known to cause ulcers/erosions and even perforation. Lower GI tract…
